JORMA JYRKKANEN
Vitamins E acts against Harmful Lipid Peroxide and Vitamin C against Reactive Oxygen to Potentially reduce Cancer Risk from Antibiotic Damaged Mitochondria
September 27, 2020
When antibiotics cause mitochondria to lose glutathione and increase ROS and Lipid Peroxide, Vitamin C and E are useful helpers to normalize impacts. Still don’t reverse loss of immune protecting microbiota in the gut and help a tad.
Vitamin C (Ascorbate)
Ascorbate has been demonstrated to be an effective antioxidant. It can act both directly, by reaction with aqueous peroxyl radicals, and indirectly, by restoring the antioxidant properties of fat-soluble vitamin E. The overall consequence of these antioxidant activities is the beneficial control of lipid peroxidation of cellular membranes including those surrounding as well as within intracellular organelles. Intracellular free radical attack on non-lipid nuclear material may also be diminished.
Vitamin E (tocopherols)
Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Clinical studies suggest a number of protective dietary factors for asthma, including vitamin E. However, studies of vitamin E in allergy commonly result in seemingly conflicting outcomes. Recent work indicates that allergic inflammation is inhibited by supplementation with the purified natural vitamin E isoform α-tocopherol but elevated by the isoform γ-tocopherol when administered at physiological tissue concentrations. In this review, we discuss opposing regulatory effects of α-tocopherol and γ-tocopherol on allergic lung inflammation in clinical trials and in animal studies. A better understanding of the differential regulation of inflammation by isoforms of vitamin E provides a basis towards the design of clinical studies and diets that would effectively modulate inflammatory pathways in lung disease.
References
Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Vitamin E isoforms as modulators of lung inflammation. Nutrients. 2013;5(11):4347-4363. Published 2013 Oct 31. doi:10.3390/nu5114347
No comments:
Post a Comment