Cannabinoids Found Causing Cancer Progression and ~4X Addiction in Thailand. 2022-11-21. Jorma Jyrkkanen

Are CANNABINOIDS Good for Cancer Therapies or do they cause or promote cancer? Its Not a Simple story.2022-11-21. Jorma Jyrkkanen STATUS AMONG REGULATORS Overview Cannabis, also known as marijuana, is a plant grown in many parts of the world. It makes a resin (thick substance) that contains compounds called cannabinoids (see Question 1). By federal law, possessing Cannabis is illegal in the United States outside of approved research settings. However, a growing number of states, territories, and the District of Columbia have passed laws to legalize medical and/or recreational marijuana (see Question 1). Cannabinoids are chemicals in Cannabis that cause drug-like effects in the body, including the central nervous system and the immune system (see Question 2). The main psychoactive cannabinoid in Cannabis is delta-9-THC. Another active cannabinoid is cannabidiol (CBD), which may relieve pain, lower inflammation, and decrease anxiety without causing the "high" of delta-9-THC (see Question 2). Cannabinoids can be taken by mouth, inhaled, or sprayed under the tongue (see Question 4). Cannabis and cannabinoids have been studied for relief of pain, nausea and vomiting, anxiety, and loss of appetite caused by cancer or the side effects of cancer therapies (see Question 6). Two cannabinoid drugs (dronabinol and nabilone) are approved by the U.S. Food and Drug Administration (FDA) for the prevention or treatment of nausea and vomiting caused by chemotherapy (see Question 6 and Question 8). The FDA has not approved Cannabis or cannabinoids for use as a cancer treatment.

University of California San Diego School of Medicine researchers have identified the molecular mechanism activated by the presence of tetrahydrocannabinol (THC) — the ingredient that causes people to feel the euphoria or “high” associated with cannabis — in the bloodstream that accelerates cancer growth in patients with human papillomavirus (HPV)-positive head and neck squamous cell carcinoma. “HPV-related head and neck cancer is one of the fastest growing cancers in the United States. While at the same time, exposure to marijuana is accelerating. This is a huge public health problem,” said Joseph A. Califano III, MD, senior author and professor and vice chief of the Division of Otolaryngology in the Department of Surgery at UC San Diego School of Medicine. Head and neck squamous cell carcinoma is the sixth most common cancer worldwide. These cancers begin in the cells that line the mucous membranes inside the mouth, nose and throat. Approximately 30 percent of cases of this disease are related to HPV infection, and it is these cases, in particular that are on the rise. Califano suggested increased marijuana use may be a driving factor. Previous studies have linked daily marijuana exposure to an increased prevalence of HPV-related throat cancer. However, a mechanism linking cannabis exposure to increased growth of the cancer was unknown. Reporting in the January 13, 2020 online edition of Clinical Cancer Research, a journal of the American Association for Cancer Research, researchers outline how the presence of THC in the bloodstream activates the p38 MAPK pathway, which controls programmed cell death called apoptosis. When activated, p38 MAPK prevents apoptosis from occurring, thus allowing cancer cells to grow uncontrollably. Working with Chao Liu, MD, visiting scientist at UC San Diego and a physician at China’s Central South University, and other colleagues, Califano and team used animal and human cell lines to show that THC turns p38 MAPK on and were able to stop the growth of HPV-positive head and neck cancer by turning off the pathway. The team then analyzed blood samples from patients with HPV-related throat cancer who had their genomes comprehensively mapped to define activated gene pathways. Similar to the cell lines, the blood samples showed p38 MAPK activation and loss of apoptosis in tumors from patients with THC in their blood. In another study Hart S, Fischer et al. found that concentrations of THC comparable with those detected in the serum of patients after THC administration accelerate proliferation of cancer cells instead of apoptosis and thereby contribute to cancer progression in patients. This has major ramifications for treatment of HPV cancers which are so prevalent at this time.

The cell cycle is normally controlled by cellular oncogenes, Rb phosphorylation and P53 Surveillance and any interference in this process can have significant consequences. These need to be examined very carefully.

Guggisberg et al. found in their review that there was insufficient evidence that marijuana has any beneficial effect on cancer.

MARIJUANA SMOKE ANALYSIS

2575 different compounds are detected (IN MARIJUANA SMOKE) of which, 670 and 536 (231 in common) are tentatively identified, and of these, 173 and 110 different compounds (69 in common) are known to cause negative health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms. QED. CASE CLOSED. WEED IS TOXIC. ANALYSIS SUMMARY: 1.There is evidence for increase in cancer spread and the mechanism is elucidated. 2.There is insufficient evidence from past studies of any beneficial effect regarding cancer. 3. Marijuana smoke is going to potentially turn peoples early HPV cancers into aggressive cancers when people are exposed to second hand smoke. 4. There is a potential for cannabis users and those exposed who have worsened cancers of more easily spreading the HPV cancers which are contracted by intimate contact and HPV containing bodily fluids and exudates. 5. The smoke contains many toxic health risk chemicals. ACTIONABLE EXPOSURES: I think a class action against the Trudeau Government is also in order for negligent homicide for failure to conduct proper pre-approval studies validating public safety and ignoring existing evidence of harm. LEGALIZATION IN THAILAND LINKED TO INCREASE IN ADDICTION BY ~4x

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Ode to Rose, My Dreams of You. A Love Poem for a Tragic Love Story. Jorma Jyrkkanen.

Jorma Jyrkkanen Ode to Rose; My Dreams of You

Jorma Jyrkkanen, Bsc, PDP {Excerpted from Return of the Pagan Fenni} I said this was a love story but more. It is also a love tragedy that two people who loved each other so much should ever be parted. But we cannot physically be in two places even though our hearts and our dreams are. This story took place in the early 1980’s in Terrace, BC. Hers was a Face that Helen of Troy would have slit her wrists upon seeing. RoseLove My Dreams of You 7 July, 1988 It was a Barbarous and Vicious jest by Fate, That You came Again. For once I Held a Woman Real, And You and She were One. In Manner, Voice, in Starry Eyes, In Radiant Loveliness Sublime, She was You and You were Her, Dream Incarnated. Cold Fate, Mockingly, Ripped Her, From My Loving Arms, and Crushed my Heart to Pulp. The Weak Soft Slippery Glue of Time, Scarce held it So, when You, You Came Again and Again. Beseeching, Smiling Coyly, You Emerged there Inside, Glowing in the Mists of Virtuality, While I Trembled to Quiet my Rumbling Soul. My One True love, You Came Back, But as A Dream. I could not Contain my Bursting Loins, Nor keep the Beast at Bay. How I Yearn to Wake in You, As You in Sleep in Me, You Darling Phantom Sprite! I am a Rabid Fool, Toy of Whimsical Fates, When You, You are Here; Cruelly must I Bear to Just Gaze Upon You, As You Invite me to Your Whispy Haunting Embrace, For to Bid Farewell at Night’s Short End, Kills my Soul Dead as Clay, How I love Thee, Thou Mustn’t Go, Stay. For Me and Thee Are not Free for Each is Still in T’Other. Forgive Me, Please I Weep, Wicked Callous Dawn Intrudes to Fade, Dearest, Know as You go, That You, are the Goal, Of My Searching Lost Soul. True Love, True Love, True Love.

Such charms not only cause the wax of passionate poetry to flow but the airs of loves musical musings. Ergo I composed this. See youtube.com/@Jormawankenobe http://www.youtube.com/watch?v=Z5jqK9DHQe0 Copyright 2001 Jorma Jyrkkanen. All rights reserved. Tags: Jorma Jyrkkanen, Love, Poem, Rose, Video

VIRUS HYBRIDS FORM FROM TWO DIFFERENT RESPIRATORY PATHOGENS RSV AND IAV. 2022-11-15. Jorma Jyrkkanen

This article is interesting to me because it shows how new pathogen variants emerge from hybridization, ie exchange of genes between pathogens with similar target hosts. Nature Microbiology. Published: 24 October 2022. Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles. Joanne Haney, Swetha Vijayakrishnan, James Streetley, Kieran Dee, Daniel Max Goldfarb, Mairi Clarke, Margaret Mullin, Stephen D. Carter, David Bhella & Pablo R. Murcia. Nature Microbiology volume 7, pages 1879–1890 (2022)Cite this article Abstract Interactions between respiratory viruses during infection affect transmission dynamics and clinical outcomes. To identify and characterize virus–virus interactions at the cellular level, we coinfected human lung cells with influenza A virus (IAV) and respiratory syncytial virus (RSV). Super-resolution microscopy, live-cell imaging, scanning electron microscopy and cryo-electron tomography revealed extracellular and membrane-associated filamentous structures consistent with hybrid viral particles (HVPs). We found that HVPs harbour surface glycoproteins and ribonucleoproteins of IAV and RSV. HVPs use the RSV fusion glycoprotein to evade anti-IAV neutralizing antibodies and infect and spread among cells lacking IAV receptors. Finally, we show that IAV and RSV coinfection in primary cells of the bronchial epithelium results in viral proteins from both viruses co-localizing at the apical cell surface. Our observations define a previously unknown interaction between respiratory viruses that might affect virus pathogenesis by expanding virus tropism and enabling immune evasion. This observation suggests pandemics are more likely to arise when several similar viral pathogens are experiencing outbreaks at the same time due to the varieties that are being created de novo. High risk activities should be curtailed when this possibility becomes probable to prevent the expansion of pathogen pandemics. It has been postulated that the AIDS virus is a hybrid produced in this manner fron visna virus and human HTLV-I. Is AIDS Man-Made? The theory that AIDS originated in the laboratory has been circulating in Europe, particularly in West Germany, since late 1986. The theory hinges on the claim that the AIDS virus (HIV) is virtually identical to two other viruses: Visna, which causes a fatal disease in sheep but does not infect humans, and HTLV-I (Human T-Cell Leukemia Virus), which infects humans but is seldom fatal. Prof. Jakob Segal, the author of the theory, says that structural analysis using genome mapping proves that HIV is more similar to Visna than to any other retrovirus. The portion (about three percent) of the HIV genome which does not correspond structurally to Visna corresponds exactly to part of the HTLV-I genome.

5G CELL PHONE EMF AND COVID, A PLAUSIBLE SYNERGISM INCREASING RISKS TO NEUROLOGICAL HEALTH VIA MITOCHONDRIAL OXIDATIVE AND DNA DAMAGE. 2022-11-14. Jorma Jyrkkanen

J Clin Transl Res. 2021 Oct 26; 7(5): 666–681. Published online 2021 Sep 29. PMCID: PMC8580522 PMID: 34778597 Evidence for a connection between coronavirus disease-19 and exposure to radiofrequency radiation from wireless communications including 5G Beverly Rubik 1 , 2 , * and Robert R. Brown 3 Abstract Background and Aim: Coronavirus disease (COVID-19) public health policy has focused on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and its effects on human health while environmental factors have been largely ignored. In considering the epidemiological triad (agent-host-environment) applicable to all disease, we investigated a possible environmental factor in the COVID-19 pandemic: ambient radiofrequency radiation from wireless communication systems including microwaves and millimeter waves. SARS-CoV-2, the virus that caused the COVID-19 pandemic, surfaced in Wuhan, China shortly after the implementation of city-wide (fifth generation [5G] of wireless communications radiation [WCR]), and rapidly spread globally, initially demonstrating a statistical correlation to international communities with recently established 5G networks. In this study, we examined the peer-reviewed scientific literature on the detrimental bioeffects of WCR and identified several mechanisms by which WCR may have contributed to the COVID-19 pandemic as a toxic environmental cofactor. By crossing boundaries between the disciplines of biophysics and pathophysiology, we present evidence that WCR may: (1) cause morphologic changes in erythrocytes including echinocyte and rouleaux formation that can contribute to hypercoagulation; (2) impair microcirculation and reduce erythrocyte and hemoglobin levels exacerbating hypoxia; (3) amplify immune system dysfunction, including immunosuppression, autoimmunity, and hyperinflammation; (4) increase cellular oxidative stress and the production of free radicals resulting in vascular injury and organ damage; (5) increase intracellular Ca2+ essential for viral entry, replication, and release, in addition to promoting pro-inflammatory pathways; and (6) worsen heart arrhythmias and cardiac disorders. Relevance for Patients: In short, WCR has become a ubiquitous environmental stressor that we propose may have contributed to adverse health outcomes of patients infected with SARS-CoV-2 and increased the severity of the COVID-19 pandemic. Therefore, we recommend that all people, particularly those suffering from SARS-CoV-2 infection, reduce their exposure to WCR as much as reasonably achievable until further research better clarifies the systemic health effects associated with chronic WCR exposure. Keywords: COVID-19, Coronavirus, coronavirus disease-19, severe acute respiratory syndrome, coronavirus 2, electromagnetic stress, electromagnetic fields, environmental factor, microwave, millimeter wave, pandemic, public health, radio frequency, radiofrequency, wireless SEE ALSO MY STUDY ON EMF AND CANCER, i FOUND CANCER OF THE BRAIN, LEUKEMIAS, DEFORMITIES AND MISCARRIAGES This is my conclusion from a massive literature review. INTRODUCTION This EMF Cancer review is based on literature references obtained from Bonneville Power, Battelle and BC Hydro, spanning 1979-1989 and from a computor search of DIALOG databases for 1989-90. I have since become aware that DIALOG has had a legal battle with CAS, Chemical Abstracts Society, and this may have led to less reporting of actual published research than that which I obtained at least for my 1989-90 computor online update, so there may be gaps. How the librarian chose which studies I would receive from the total list I asked for is not clear so a source of bias could have been enterred there. It has also been argued that findings which show no effects are less likely to get published. I seriously question this however, since it is in the vested interests of utilities to make widely known any such null effects, and they would promote the publication of such studies. If anything, perhaps the reverse is true. Perhaps these two tendencies cancel out and a truly representative pattern of negative and positive findings is in fact published. There is a massive problem with controls in the majority of these studies since EMF is so wide-spread, it is almost impossible to get an unexposed group. The best that can be hoped for is a less exposed group. However, even this runs into trouble interpretation-wise when one considers that specific windows of frequency and intensity and combinations may be more important in causality than simple density of electric or magnetic fields. The effect of using national averages as controls where even the controls have been exposed to EMF to some degree, is to underestimate the true effect of EMF so that5 it is safe to say that it is worse than experimentally demonstrated. RESULTS The conclusions one is drawn to from an overview such as this are inescapable. EMF or something to do with EMF makes leukemia worse if not actually causing it or some forms of it, though the evidence points strongly towards causality. Brain cancer is made worse or actually caused by EMF or an associated factor. Other cancers are probably made worse or promoted by EMF exposure. Fundamental genetic and perhaps epigenetic cellular physiology changes occur, some permanently, from certain tunings or windows of EMF. Effects on development can be profound and species variability in susceptability to EMF impacts is largely unknown. Confounding variables like chemical pollutants, solvent vapors, metals, may be operative synergistically as initiators, promoters, physiological poisons, hormone analogs, or cocarcinogens or may work through harming the immune system. CONCLUSION MITOCHONDRIAL OXIDATION DAMAGE INDUCED BY EMF Exposure to 900 MHz EMF has provided evidence of causation of blood-brain barrier damage, induction of glial reactivity, and initiation of biochemical modifications in the rat brain (17, 27). Xu et al. (28) determined that exposure to 1,800 MHz RF EMF promoted oxidative damage to mitochondrial DNA and changed the activity of neuron function. Dindic et al. (8) reported biochemical and histopathological changes after MP exposure on rat brain. REFERENCE: WU ET. AL. ABSTRACT FINDS MECHANISM FOR NEUROTOXICITY OF CELL PHONE FREQUENCIES we exposed primary cultured cortical neurons to pulsed RF electromagnetic fields at a frequency of 1800 MHz modulated by 217 Hz at an average special absorption rate (SAR) of 2 W/kg. At 24 h after exposure, we found that RF radiation induced a significant increase in the levels of 8-hydroxyguanine (8-OHdG), a common biomarker of DNA oxidative damage, in the mitochondria of neurons. Concomitant with this finding, the copy number of mtDNA and the levels of mitochondrial RNA (mtRNA) transcripts showed an obvious reduction after RF exposure. Each of these mtDNA disturbances could be reversed by pretreatment with melatonin, which is known to be an efficient antioxidant in the brain. Together, these results suggested that 1800 MHz RF radiation could cause oxidative damage to mtDNA in primary cultured neurons. Oxidative damage to mtDNA may account for the neurotoxicity of RF radiation in the brain. It is safe to conclude from a reading of the totality of studies relating EMF to cancer, to which I have accessed so far, that EMF is a highly probable cancer hazard contributing worldwide to significantly increased human and non-human morbidity and mortality. While it may be more statistically formal to do a Meta-Analysis on the studies (Mann, C. 1990. Meta-Analysis in the Breech. Science (249):476-480.), the trends are so strong that I doubt that any significant change in the final interpretation would result. DAMAGE TO MITOCHONDRIAL DNA WOULD ALSO BE COMPOUNDED WITH COVID ATTACK ON MITOCHONDRIA ALSO DAMAGING THE DNA AND EVEN POSSIBLY RUPTURING THE MITOCHONDRIA. THIS WOULD CREATE A DOUBLE HIT ON THIS VITAL ORGANELLE. ANTIBIOTICS ADMINISTERED TO PATIENTS DURING TREATMENT CAN ALSO DAMAGE THE MITOCHONDRIA. THIS SORT OF DAMAGE IS LINKED TO HEART DISEASE AND CANCER (J. JYRKKANEN AUG 2021).

Existentially Critical Climate and Environment Policy Issues Needing Immediate attention to Ward off Extinction. Two Videos. 2022-11-11. Jorma Jyrkkanen

ARE WE NEARING THE FATE OF THE DINOSAURS WITH FOSSIL FUEL LEADING THE ACCELERATOR?

TO VIEW MY CLIMATE SCIENCE SITUATION REPORT VIDEO AND THE CANADIAN ENVIRONMENT POLICY VIDEO GOOGLE Jormawankenobe and open Playlist TOXICOLOGY.