Epigenetics in Cortisol Metabolism has Generational Effects on Psychological Normalcy. Can a Drug like St. John's Wort Reverse it or Provide a Therapy? If so Can it be used to Reinstate Genes Silenced in Cancers?2022-08-30 Jorma Jyrkkanen

St John’s Wort and Cortisol Potential for Reversing Epigenetic Methylation Gene Silencing and Potential Anti-Cancer Drug. Jorma Jyrkkanen, Bsc, PDP. Environmental Consultant. 2022-08-30 Introduction It has been discovered that epigenetic changes due to trauma in parents can be transferred to offspring and appear as mental instability and cortisol insufficiency is implicated in this with culprit genes identified (Rachel Yehuda in Scientific American. (1 July 2022). Main Cortisol Functions While it would be difficult to name all of the functions of cortisol, here are some of its prime responsibilities: • Cortisol prepares the body to deal with stress or danger. ⁷ • Cortisol helps control blood sugar and blood pressure. ⁷ • Cortisol regulates how the body uses food and gets energy—your metabolism. ⁷ • Cortisol plays a role in helping the brain form memories. ⁶ • Cortisol helps the body recognize when it is time to sleep and when to wake up. ⁵ Epigenetic Inheritance Could some of these epigenetic changes in trauma survivors also be found in the children of trauma survivors? Finding low cortisol in the 9/11 babies back in 2002 had told us that we'd been thinking about some things all wrong. We'd assumed all along that trauma was behaviorally transmitted: Joseph's problems seemed to result from the stressful, bereaved atmosphere in his childhood home. But now it looked like the uterine environment also played a role. So did the sex of the traumatized parent. In our early studies of Holocaust offspring, we had selected only those people with two parents who were Holocaust survivors. We redid the studies to figure out if the sex of the parent mattered—and it did. Those whose mother (or both parents) had PTSD tended to exhibit lower cortisol levels and showed evidence of more sensitive glucocorticoid receptors. In contrast, those whose fathers, but not mothers, had PTSD showed the opposite effect. Taking a closer look, we again discovered lower methylation within the glucocorticoid receptor gene, NR3C1, in Holocaust offspring whose mothers, or both parents, had PTSD. These changes mirrored what we'd observed in the maternal survivors themselves. But in offspring with only paternal PTSD, we observed more methylation—the opposite effect. These findings raised the possibility that PTSD in mothers and fathers might lead to different epigenetic changes on the glucocorticoid receptor in children. In a second series of studies beginning in 2016, we examined methylation within another gene, FKBP5, which encodes a protein involved in regulating the ability of the glucocorticoid receptor to bind cortisol. The findings showed related methylation patterns within the FKBP5 gene in both Holocaust parents and their children. But because of the small number of participants in that study—by this time it was difficult to find many living Holocaust survivors who could participate with their offspring—we couldn't examine how factors such as the parents' PTSD status might contribute to FKBP5 methylation. We were able to replicate and extend this work in a substantially larger sample of just the Holocaust offspring, however. In 2020 we reported lower levels of FKBP5 methylation in the adult children whose mothers—and not fathers—were exposed to the Holocaust during childhood. This effect was independent of whether the mother had PTSD or not. It suggested that trauma might have affected the mothers' eggs decades before her children were conceived, while she was herself a child. Given the obvious difficulties in studying generations of people, scientists often resort to animal studies to explore epigenetic transmission. In 2014 Brian Dias and Kerry Ressler, both at the Emory University School of Medicine, reported an intergenerational epigenetic pathway that ran through sperm. They gave a male mouse a mild electric shock as it smelled a cherry blossom scent, stimulating a fear response to the odor. The response was accompanied by epigenetic changes in its brain and sperm. Intriguingly, the male offspring of the shocked mice demonstrated a similar fear of cherry blossoms—as well as epigenetic changes in their brain and sperm—without being exposed to the shock. These effects were passed down for two generations. In other words, the lesson the grandfather mouse learned, that the cherry blossom scent means danger, was transmitted to its son and grandson. In a recent study, my colleagues and I experimented with genome-wide gene expression, a tool that can identify links between protein expression and specific conditions across the entire human genome. With this approach, we again observed distinct patterns of gene expression linked with maternal and paternal trauma exposure and PTSD (Sci.Am). Was the low Cortisol due to epigenetic silencing of CpG segments of the genes in question? A Substance that Reverses the Mental Effects of Low Cortisol St John’s Wort Drugs That Affect Cortisol Doctor's answers | Diagnosis, Doctor's Answers Question:  I’ve read that lots of common medicines and treatments can raise or lower cortisol.  There’s not much mention of the quantity of these meds that affect cortisol though.  Xanax and codeine lower, for example, and Zoloft, Ritalin, St. John’s Wort, alcohol, and even marijuana raise cortisol.  Growth and thyroid hormones are reported to lower cortisol.  What the Science Says About the Effectiveness of St.  John’s Wort for  Depression The results of studies on the effectiveness of St. John’s wort for depression are mixed. • In a 12-week, 2011 clinical trial with 73 participants, neither St. John’s wort nor a standard antidepressant medication called citalopram, a selective serotonin reuptake inhibitor (SSRI), decreased symptoms of minor depression better than a placebo. The study was funded by NCCIH and NIMH. • In a 26-week clinical trial with 124 participants, St. John’s wort, a standard antidepressant (sertraline, an SSRI), and a placebo were similarly effective in treating major depression of moderate severity. NCCIH and NIMH funded this 2012 analysis of data collected in 2002. • A 2008 review of 29 international studies suggested that St. John’s wort may be better than a placebo and as effective as different standard prescription antidepressants for major depression of mild to moderate severity. St. John’s wort also appeared to have fewer side effects than standard antidepressants. The studies conducted in German-speaking countries—where St. John’s wort has a long history of use by medical professionals—reported more positive results than those done in other countries, including the United States. • St. John’s wort was no more effective than placebo in treating major depression of moderate severity, an NCCIH- and NIMH-funded study of 340 participants reported in 2002. (NIH Info) Minireview: Stress-related psychiatric disorders with low cortisol levels: a metabolic hypothesis Rachel Yehuda  1 , Jonathan Seckl Affiliations • PMID: 21971152 • DOI: 10.1210/en.2011-1218 Abstract Several stress-associated neuropsychiatric disorders, notably posttraumatic stress disorder and chronic pain and fatigue syndromes, paradoxically exhibit somewhat low plasma levels of the stress hormone cortisol. The effects appear greatest in those initially traumatized in early life, implying a degree of developmental programming, perhaps of both lower cortisol and vulnerability to psychopathology. In these conditions, lowered cortisol is not due to any adrenal or pituitary insufficiency. Instead, two processes appear involved. First, there is increased target cell sensitivity to glucocorticoid action, notably negative feedback upon the hypothalamic-pituitary-adrenal (stress) axis. Altered density of the glucocorticoid receptor is inferred, squaring with much preclinical data showing early life challenges can permanently program glucocorticoid receptors in a tissue-specific manner. These effects involve epigenetic mechanisms. Second, early life trauma/starvation induces long-lasting lowering of glucocorticoid catabolism, specifically by 5α-reductase type 1 (predominantly a liver enzyme) and 11β-hydroxysteroid dehydrogenase type 2 (in kidney), an effect also seen in model systems. These changes reflect a plausible early-life adaptation to increase the persistence of active cortisol in liver (to maximize fuel output) and kidney (to increase salt retention) without elevation of circulating levels, thus avoiding their deleterious effects on brain and muscle. Modestly lowered circulating cortisol and increased vulnerability to stress-associated disorders may be the outcome. This notion implies a vulnerable early-life phenotype may be discernable and indicates potential therapy by modest glucocorticoid replacement. Indeed, early clinical trials with cortisol have shown a modicum of promise. Potential to Explore If St. John's Wort raises Cortisol epigenetically by removing methylation from the CpG regions of genes it may have anti cancer drug potential and possibly heritable anti cancer drug potential. This might be worth more detailed investigation.

Oxford Covid Study Reported in The Lancet Psychiatry on After effects and Financial Times UK 2022-09-01. Jorma Jyrkkanen

sequelae post infection Neurological For months now, studies of COVID patients have suggested that contracting the disease could lead to neurological conditions like dementia and ‘brain fog, but a new study from Oxford researchers shows just how long the risk can last. The study, published in The Lancet Psychiatry on Wednesday, found that the risk of disorders like cognitive deficit (also known as ‘brain fog’), psychotic disorders, and epilepsy was elevated even two years after a COVID diagnosis. Researchers analyzed data from almost 1.5 million COVID patients sourced from TriNetX, which compiles health records from 89 million patients across eight countries. Researchers compared COVID patients to an equal number of patients diagnosed with a non-COVID respiratory infection, who acted as a control group. COVID patients were 36 times more likely to be diagnosed with cognitive deficit and 33 times more likely to be diagnosed with dementia six months after catching COVID. Not just the Brain Scientists are still investigating just how broadly COVID affects the body. Catching the disease has been tied to chronic fatigue, muscle weakness, hair loss, erectile dysfunction, stroke, and cardiovascular illness. Last week, a study from the Yale School of Medicine and the Icahn School of Medicine at Mount Sinai found lower rates of cortisol, a stress hormone, in those with long COVID. Low levels of cortisol have been tied to muscle weakness and fatigue. 130 www.thelancet.com/psychiatry Vol 8 February 2021Articles Lancet Psychiatry 2021; 8: 130–40 Published Online November 9, 2020 https://doi.org/10.1016/ S2215-0366(20)30462-4 This online publication has been corrected. The corrected version first appeared at thelancet.com/psychiatry on November 12, 2020 See Comment page 89 Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK (M Taquet PhD, Prof J R Geddes FRCPsych, Prof P J Harrison FRCPsych); Oxford Health NHS Foundation Trust, Oxford, UK (M Taquet, Prof J R Geddes, Prof P J Harrison); and TriNetX, Cambridge, MA, USA (S Luciano BA) Correspondence to: Prof Paul J Harrison, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK paul.harrison@psych.ox.ac.uk Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA Maxime Taquet, Sierra Luciano, John R Geddes, Paul J Harrison Heart and Mind

US INTERNATIONAL BIOLAB CLIPS. 2022-08-03. JORMA JYRKKANEN

THERE IS A VERY ACTIVE ATTEMPT TO BLOCK STORIES ABOUT AMERICAN MILITARY BIOLABS AROUND THE WORLD. AMERICA IS EMBARRASSED ABOUT THIS CRIME AND TRYING TO HIDE IT. WHO DID IT, MADE THE COVID 19 BIOWEAPON. ULTIMATELY. Truth Justice ™ @SpartaJustice BREAKING NEWS: The FDA was involved in the development of Covid-19 as an offensive biological warfare weapon at UNCBSL3. The Pentagon bought and paid for the toxic mRNA shots and helped create Covid-19. All are guilty of Nuremberg crimes, murder and conspiracy to commit murder. The CDC Director Rochelle Walensky is also accountable for these murders and Nuremberg crimes. The Harvard Medical School was also involved in the development of Covid-19 at the UNCBSL3 lab with Ralph Baric along with the FDA. The CDC has long been involved in offensive biological weapons dating back to the Reagan Administration. The Reagan Administration authorized the CDC to ship biological warfare agents to Saddam Hussein in Iraq hoping he would use them against Iran. U.S. International Lawyer Professor Francis Boyle states the end goal of DARPA, the Pentagon, the FDA, the CDC, the CIA, Bill Gates, Klaus Schwab, Ralph Baric, Peter Daszak, Anthony Fauci, the Rockefellers, Rothschilds and many others is population control and reduction while making billions of dollars. New reports show worldwide excess deaths of 12 million innocent people. Professor Boyle drafted the U.S. domestic implementing legislation for the Biological Weapons Convention, known as the Biological Weapons Anti-Terrorism Act of 1989, that was approved unanimously by both Houses of the U.S. Congress and signed into law by President George H.W. Bush. Professor Boyle has also advised numerous international bodies in the areas of human rights, war crimes and genocide, nuclear policy, and bio-warfare. From 1991-92, he served as Legal Advisor to the Palestinian Delegation to the Middle East Peace Negotiations. He goes on to say that the population control and reduction objective goes back to the National Security directive by the Henry Kissinger Report written in 1974 which stated that it was in the best interest of National Security for the United States and for Overseas Interests to have a population control and reduction policy. The National Security Study Memorandum NSSM200 Implications of Worldwide Population Growth For U.S. Security and Overseas Interests (THE KISSINGER REPORT) dated December 10, 1974 was Classified and Confidential until it was Declassified on 7/3/89. Read the entire report to understand what they are doing. All citizens of the world are strongly encouraged to go to their local Sheriff's Office, Police Office and District or State Attorney General's Office and file criminal charges of murder and conspiracy to commit murder, demanding that the people responsible be arrested and prosecuted. This must be done, be brave and act now humanity. The Chinese Communist Government also helped the Pentagon and the FDA create Covid-19. They new they were developing a dangerous offensive biological warfare weapon with gain of function properties that had HIV DNA genetically engineered into it and was combined with nanotechnology in order to aerosolize it enabling the bioweapon to travel up to 30 feet in the air. They deliberately created both biological warfare weapons Covid-19 and the lethal Covid vaccines long before the Pandemic and then they created a fraudulent Pandemic in order to release these deadly biological weapons of war on humanity to kill millions of innocent people worldwide. 39.1K views 0:03 / 17:16 11:37 AM · Apr 14, 2023 · 125.2K Views

excellent video https://www.youtube.com/watch?v=_8hQi2Zv1L0

NEEDED NOW AN INTERNATIONAL BIOLAB NON-PROLIFERATION AGREEMENT AT UN