Amyotropic lateral sclerosis ALS and dioxin 2,3,7,8-TCDD may be causally linked. Mar. 4th, 2010 Supported by Later Studies. Jorma Jyrkkanen

Amyotropic lateral sclerosis and dioxin may be causally linked. Validated by later studies. Mar. 4th, 2010 at 5:34 AM. Jorma Jyrkkanen

In fish exposed to dioxins, the first symptom is finrot. Degeneration of periferal extremities. It is irreversible and begins with an extremely small exposure. We see in ALS a similar degeneration of the extremities. This leads me to suspect that dioxins and possibly furans and PCB's are involved ALS causality. I should like to do a statistical test to affirm this. Gallagher found elevated neurodegenerative disease in School Districts in BC with Pulp Mills, which incidentally emit dioxins, furans and a host of other organochlorines supporting my hypothesis. I believe that a proper epidemiological test could put the matter of ALS to rest. ©2010 Jorma Jyrkkanen. All rights reserved. Tags:ALS, dioxin, causality, Jorma Jyrkkanen, epidemiology Tags: als, causality, dioxin, epidemiology, jorma jyrkkanen Dioxins and related environmental contaminants increase TDP-43 levels Peter E. A. Ash, Elizabeth A. Stanford, Ali Al Abdulatif, Alejandra Ramirez-Cardenas, Heather I. Ballance, Samantha Boudeau, Amanda Jeh, James M. Murithi, Yorghos Tripodis, George J. Murphy, David H. Sherr & Benjamin Wolozin Molecular Neurodegeneration volume 12, Article number: 35 (2017) Cite this article 2539 Accesses 16 Citations 13 Altmetric Metricsdetails Abstract Background Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative condition that is characterized by progressive loss of motor neurons and the accumulation of aggregated TAR DNA Binding Protein-43 (TDP-43, gene: TARDBP). Increasing evidence indicates that environmental factors contribute to the risk of ALS. Dioxins, related planar polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants that activate the aryl hydrocarbon receptor (AHR), a ligand-activated, PAS family transcription factor. Recently, exposure to these toxicants was identified as a risk factor for ALS. Eureka ALS cause found. Pulp mills carcinogens and mutagens and some EDs. I suggested dioxin caused ALS in 2010 and this is supported by subsequent research. I presented details of this list as Intervenor at Al Pac hesrings. It is Found in BKME effluent. Agent Orange and other sources.

s 2,3,7,8-TCDD.