Natural Supplements to improve mitochondrial function or long covid sufferers. 2022-02-09 Jorma Jyrkkanen

Integr Med (Encinitas). 2014 Aug; 13(4): 35–43. PMCID: PMC4566449 PMID: 26770107 Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements Garth L. Nicolson, PhD Author information Copyright and License information Disclaimer This article has been cited by other articles in PMC. Go to: Abstract Loss of function in mitochondria, the key organelle responsible for cellular energy production, can result in the excess fatigue and other symptoms that are common complaints in almost every chronic disease. At the molecular level, a reduction in mitochondrial function occurs as a result of the following changes: (1) a loss of maintenance of the electrical and chemical transmembrane potential of the inner mitochondrial membrane, (2) alterations in the function of the electron transport chain, or (3) a reduction in the transport of critical metabolites into mitochondria. In turn, these changes result in a reduced efficiency of oxidative phosphorylation and a reduction in production of adenosine-5′-triphosphate (ATP). Several components of this system require routine replacement, and this need can be facilitated with natural supplements. Clinical trials have shown the utility of using oral replacement supplements, such as l-carnitine, alpha-lipoic acid (α-lipoic acid [1,2-dithiolane-3-pentanoic acid]), coenzyme Q10 (CoQ10 [ubiquinone]), reduced nicotinamide adenine dinucleotide (NADH), membrane phospholipids, and other supplements. Combinations of these supplements can reduce significantly the fatigue and other symptoms associated with chronic disease and can naturally restore mitochondrial function, even in long-term patients with intractable fatigue. See also my suggestions on this subject.