Oxford Covid Study Reported in The Lancet Psychiatry on After effects and Financial Times UK 2022-09-01. Jorma Jyrkkanen

sequelae post infection Neurological For months now, studies of COVID patients have suggested that contracting the disease could lead to neurological conditions like dementia and ‘brain fog, but a new study from Oxford researchers shows just how long the risk can last. The study, published in The Lancet Psychiatry on Wednesday, found that the risk of disorders like cognitive deficit (also known as ‘brain fog’), psychotic disorders, and epilepsy was elevated even two years after a COVID diagnosis. Researchers analyzed data from almost 1.5 million COVID patients sourced from TriNetX, which compiles health records from 89 million patients across eight countries. Researchers compared COVID patients to an equal number of patients diagnosed with a non-COVID respiratory infection, who acted as a control group. COVID patients were 36 times more likely to be diagnosed with cognitive deficit and 33 times more likely to be diagnosed with dementia six months after catching COVID. Not just the Brain Scientists are still investigating just how broadly COVID affects the body. Catching the disease has been tied to chronic fatigue, muscle weakness, hair loss, erectile dysfunction, stroke, and cardiovascular illness. Last week, a study from the Yale School of Medicine and the Icahn School of Medicine at Mount Sinai found lower rates of cortisol, a stress hormone, in those with long COVID. Low levels of cortisol have been tied to muscle weakness and fatigue. 130 www.thelancet.com/psychiatry Vol 8 February 2021Articles Lancet Psychiatry 2021; 8: 130–40 Published Online November 9, 2020 https://doi.org/10.1016/ S2215-0366(20)30462-4 This online publication has been corrected. The corrected version first appeared at thelancet.com/psychiatry on November 12, 2020 See Comment page 89 Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK (M Taquet PhD, Prof J R Geddes FRCPsych, Prof P J Harrison FRCPsych); Oxford Health NHS Foundation Trust, Oxford, UK (M Taquet, Prof J R Geddes, Prof P J Harrison); and TriNetX, Cambridge, MA, USA (S Luciano BA) Correspondence to: Prof Paul J Harrison, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK paul.harrison@psych.ox.ac.uk Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA Maxime Taquet, Sierra Luciano, John R Geddes, Paul J Harrison Heart and Mind