Can Antiviral Drug and Vaccine Administration Harm Existing Repurposed Viral Genomes( 8%), Retroviral(40%) Fragment Functions in the Human Genome? 2022-10-03. Jorma Antero Jyrkkanen

Can Antiviral Drug and Vaccine Administration Harm Existing Repurposed Viral Genomes( 8%), Retroviral(40%) Fragment Functions in the Human Genome? INTRODUCTION We once spent time living without medicines and drugs and vaccines the life of a an insectivorous tree shrew-like creature and later like a slow Lori on the road to high primate. During those times we were also exposed to the ancestors of covid and all other viral zoonoses and subjected to the rigors of immune challenge with weak systems failing and strong ones enabling us to get to the next level of evolution through death by natural selection. We were the Zoo in Zoonoses. Those ancient viral genes didn't leave us completely during that challenge. Some went on to become part of what we are today, and for each individual whose genes differ it leaves us with diverse innate immunity to new variant challenges.

Eight percent of our DNA consists of remnants of ancient viruses, and another 40 percent is made up of repetitive strings of genetic letters that is also thought to have a viral origin. Those extensive viral regions are much more than evolutionary relics: They may be deeply involved with a wide range of diseases including multiple sclerosis, hemophilia, and amyotrophic lateral sclerosis (ALS), along with certain types of dementia and cancer. When we administer antivirals of any kind even vaccines to people by any means we need to predetermine that they don't harm any functions of the 8% repurposed viral genomes incorporated into the human genome for example ARC and Syncytium genes. EXAMPLES OF GENES AT RISK FROM ANTIVIRALS HERV-W. SCHIZOPHRENIA Schizophrenia is a complex disorder, characterized by the interplay between genetic and environmental factors. Human endogenous retroviruses (HERVs), genetic elements that originated from infections by exogenous retroviruses millions of years ago, comprise ~8% of the human genome. Here, we provide a comprehensive review of accumulating evidence, detailing HERV aberrancies associated with schizophrenia. Studies examining the genome, transcriptome, and proteome of individuals with schizophrenia provide data that support the association of these viral elements with the disorder. Molecular differences can be found within the central nervous system and peripheral tissues. However, additional studies are needed to substantiate the reported link and to address several discrepancies among previous investigations. We further discuss potentially relevant pathogenic mechanisms to the development of schizophrenia (Human Endogenous Retroviruses as Pathogenic Factors in the Development of Schizophrenia. Gorjan Slokar1 and Gregor Hasler, Front Psychiatry. 6: 183 Jan 11 2016. THE ARC GENE, A SUSPECTED RETROVIRUS CAPSID INVOLVED IN NORMAL NEURONAL FUNCTION

ASTROCYTES, A type of brain cell that plays a role in ALS, the degenerative disease that scientists suspect might be caused by ancient viruses in our DNA, may be affected by antivirals.

SYNCYTINS 1,2 INVOLVED IN FUSION EVENTS DURING EMBRYOGENESIS, MORPHOGENESIS, REPRODUCTIVE CANCERS Human life begins with sperm and oocyte fusion. After fertilization, various fusion events occur during human embryogenesis and morphogenesis. For example, the fusion of trophoblastic cells constitutes a key process for normal placental development. Fusion in the placenta is facilitated by syncytin 1 and syncytin 2. These syncytins arose from retroviral sequences that entered the primate genome 25 million and more than 40 million years ago respectively. About 8% of the human genome consists of similar human endogenous retroviral (HERVs) sequences. Many are inactive because of mutations or deletions. However, the role of the few that remain transcriptionally active has not been fully elucidated. Syncytin proteins maintain cell–cell fusogenic activity based on env gene-mediated viral cell entry. In this review, we summarize how syncytins and their receptors are involved in fusion events during human reproduction. The significance of syncytins in tumorigenesis is also discussed (The role of syncytins in human reproduction and reproductive organ cancersin ReproductionAuthors: Bikem Soygur1 and Leyla Sati1. Nov 2016 REPRODUCTION)

The 40% of our genome thought to be of viral origin may play crucial roles in many functions such as protein integrity and epigenetic gene expression. These need to be asessed if the antiviral is be be certain to be safe. If these safeguards are not checked the antivirals are little more than experimental. HERE ARE JUST A FEW SAMPLES FROM OUR GENOME THAT NEED TO BE ASSESSED FOR SIDE EFEECTS OF ANTIVIRALS.

RETROVIRUSES IN SCHIZOPHRENIA

RETROVIRUSES IN CANCER

RETROVIRUSES IN NEUROLOGY

It is vitally important to hold the producers of drugs that destroy ancient genes to a very high standard of scientific rigor or possibly do irreparable harm to future generations. The answer to the question I pose in the title is that we don't have a clue what we are doing genetically or epigenetically in the long term. There may be short term gains in health parameters like survival but the future cost will have to wait for long term assessment if anyone is around to do that. Here is a hint that perhaps I am right.