5G CELL PHONE EMF AND COVID, A PLAUSIBLE SYNERGISM INCREASING RISKS TO NEUROLOGICAL HEALTH VIA MITOCHONDRIAL OXIDATIVE AND DNA DAMAGE. 2022-11-14. Jorma Jyrkkanen

J Clin Transl Res. 2021 Oct 26; 7(5): 666–681. Published online 2021 Sep 29. PMCID: PMC8580522 PMID: 34778597 Evidence for a connection between coronavirus disease-19 and exposure to radiofrequency radiation from wireless communications including 5G Beverly Rubik 1 , 2 , * and Robert R. Brown 3 Abstract Background and Aim: Coronavirus disease (COVID-19) public health policy has focused on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and its effects on human health while environmental factors have been largely ignored. In considering the epidemiological triad (agent-host-environment) applicable to all disease, we investigated a possible environmental factor in the COVID-19 pandemic: ambient radiofrequency radiation from wireless communication systems including microwaves and millimeter waves. SARS-CoV-2, the virus that caused the COVID-19 pandemic, surfaced in Wuhan, China shortly after the implementation of city-wide (fifth generation [5G] of wireless communications radiation [WCR]), and rapidly spread globally, initially demonstrating a statistical correlation to international communities with recently established 5G networks. In this study, we examined the peer-reviewed scientific literature on the detrimental bioeffects of WCR and identified several mechanisms by which WCR may have contributed to the COVID-19 pandemic as a toxic environmental cofactor. By crossing boundaries between the disciplines of biophysics and pathophysiology, we present evidence that WCR may: (1) cause morphologic changes in erythrocytes including echinocyte and rouleaux formation that can contribute to hypercoagulation; (2) impair microcirculation and reduce erythrocyte and hemoglobin levels exacerbating hypoxia; (3) amplify immune system dysfunction, including immunosuppression, autoimmunity, and hyperinflammation; (4) increase cellular oxidative stress and the production of free radicals resulting in vascular injury and organ damage; (5) increase intracellular Ca2+ essential for viral entry, replication, and release, in addition to promoting pro-inflammatory pathways; and (6) worsen heart arrhythmias and cardiac disorders. Relevance for Patients: In short, WCR has become a ubiquitous environmental stressor that we propose may have contributed to adverse health outcomes of patients infected with SARS-CoV-2 and increased the severity of the COVID-19 pandemic. Therefore, we recommend that all people, particularly those suffering from SARS-CoV-2 infection, reduce their exposure to WCR as much as reasonably achievable until further research better clarifies the systemic health effects associated with chronic WCR exposure. Keywords: COVID-19, Coronavirus, coronavirus disease-19, severe acute respiratory syndrome, coronavirus 2, electromagnetic stress, electromagnetic fields, environmental factor, microwave, millimeter wave, pandemic, public health, radio frequency, radiofrequency, wireless SEE ALSO MY STUDY ON EMF AND CANCER, i FOUND CANCER OF THE BRAIN, LEUKEMIAS, DEFORMITIES AND MISCARRIAGES This is my conclusion from a massive literature review. INTRODUCTION This EMF Cancer review is based on literature references obtained from Bonneville Power, Battelle and BC Hydro, spanning 1979-1989 and from a computor search of DIALOG databases for 1989-90. I have since become aware that DIALOG has had a legal battle with CAS, Chemical Abstracts Society, and this may have led to less reporting of actual published research than that which I obtained at least for my 1989-90 computor online update, so there may be gaps. How the librarian chose which studies I would receive from the total list I asked for is not clear so a source of bias could have been enterred there. It has also been argued that findings which show no effects are less likely to get published. I seriously question this however, since it is in the vested interests of utilities to make widely known any such null effects, and they would promote the publication of such studies. If anything, perhaps the reverse is true. Perhaps these two tendencies cancel out and a truly representative pattern of negative and positive findings is in fact published. There is a massive problem with controls in the majority of these studies since EMF is so wide-spread, it is almost impossible to get an unexposed group. The best that can be hoped for is a less exposed group. However, even this runs into trouble interpretation-wise when one considers that specific windows of frequency and intensity and combinations may be more important in causality than simple density of electric or magnetic fields. The effect of using national averages as controls where even the controls have been exposed to EMF to some degree, is to underestimate the true effect of EMF so that5 it is safe to say that it is worse than experimentally demonstrated. RESULTS The conclusions one is drawn to from an overview such as this are inescapable. EMF or something to do with EMF makes leukemia worse if not actually causing it or some forms of it, though the evidence points strongly towards causality. Brain cancer is made worse or actually caused by EMF or an associated factor. Other cancers are probably made worse or promoted by EMF exposure. Fundamental genetic and perhaps epigenetic cellular physiology changes occur, some permanently, from certain tunings or windows of EMF. Effects on development can be profound and species variability in susceptability to EMF impacts is largely unknown. Confounding variables like chemical pollutants, solvent vapors, metals, may be operative synergistically as initiators, promoters, physiological poisons, hormone analogs, or cocarcinogens or may work through harming the immune system. CONCLUSION MITOCHONDRIAL OXIDATION DAMAGE INDUCED BY EMF Exposure to 900 MHz EMF has provided evidence of causation of blood-brain barrier damage, induction of glial reactivity, and initiation of biochemical modifications in the rat brain (17, 27). Xu et al. (28) determined that exposure to 1,800 MHz RF EMF promoted oxidative damage to mitochondrial DNA and changed the activity of neuron function. Dindic et al. (8) reported biochemical and histopathological changes after MP exposure on rat brain. REFERENCE: WU ET. AL. ABSTRACT FINDS MECHANISM FOR NEUROTOXICITY OF CELL PHONE FREQUENCIES we exposed primary cultured cortical neurons to pulsed RF electromagnetic fields at a frequency of 1800 MHz modulated by 217 Hz at an average special absorption rate (SAR) of 2 W/kg. At 24 h after exposure, we found that RF radiation induced a significant increase in the levels of 8-hydroxyguanine (8-OHdG), a common biomarker of DNA oxidative damage, in the mitochondria of neurons. Concomitant with this finding, the copy number of mtDNA and the levels of mitochondrial RNA (mtRNA) transcripts showed an obvious reduction after RF exposure. Each of these mtDNA disturbances could be reversed by pretreatment with melatonin, which is known to be an efficient antioxidant in the brain. Together, these results suggested that 1800 MHz RF radiation could cause oxidative damage to mtDNA in primary cultured neurons. Oxidative damage to mtDNA may account for the neurotoxicity of RF radiation in the brain. It is safe to conclude from a reading of the totality of studies relating EMF to cancer, to which I have accessed so far, that EMF is a highly probable cancer hazard contributing worldwide to significantly increased human and non-human morbidity and mortality. While it may be more statistically formal to do a Meta-Analysis on the studies (Mann, C. 1990. Meta-Analysis in the Breech. Science (249):476-480.), the trends are so strong that I doubt that any significant change in the final interpretation would result. DAMAGE TO MITOCHONDRIAL DNA WOULD ALSO BE COMPOUNDED WITH COVID ATTACK ON MITOCHONDRIA ALSO DAMAGING THE DNA AND EVEN POSSIBLY RUPTURING THE MITOCHONDRIA. THIS WOULD CREATE A DOUBLE HIT ON THIS VITAL ORGANELLE. ANTIBIOTICS ADMINISTERED TO PATIENTS DURING TREATMENT CAN ALSO DAMAGE THE MITOCHONDRIA. THIS SORT OF DAMAGE IS LINKED TO HEART DISEASE AND CANCER (J. JYRKKANEN AUG 2021).