CANCER LINKS TO PARASITISM BRINGS CHEAP AVAILABLE REMEDIES. Jorma Jyrkkanen, Research Scientist, 2026-05-12

CANCER PARASITE CONNECTION AND NEW TREATMENT SUCCESSES, Jorma Jyrkkanen, Researcher. 2026-05-12 1. Parasites Can Cause Cancer. Jorma Jyrkkanen Researcher 2025-03-16 Abstract Parasites have been increasingly recognized as potential causative agents in cancer development, with a growing body of literature highlighting their role in carcinogenesis. Certain parasitic infections are strongly associated with specific malignancies, primarily through chronic inflammation, immune modulation, and direct cellular damage. The International Agency for Research on Cancer (IARC) classifies helminths such as Schistosoma haematobium, Opisthorchis viverrini, and Clonorchis sinensis as Group 1 carcinogens, linking them to bladder cancer and cholangiocarcinoma, respectively. S. haematobium induces bladder cancer via chronic inflammation and genotoxic effects from egg deposition, while liver flukes (O. viverrini and C. sinensis) promote cholangiocarcinoma through oxidative stress, cellular proliferation, and excretory-secretory products that disrupt host DNA. Additionally, protozoan parasites like Cryptosporidium parvum have been implicated in colorectal adenocarcinoma, potentially through similar inflammatory and genotoxic mechanisms. Other parasites, such as Theileria spp., induce host cell transformation, resembling cancer-like states, while Plasmodium falciparum is epidemiologically tied to endemic Burkitt lymphoma as a co-carcinogenic factor with Epstein-Barr virus. Experimental studies further suggest that parasitic infections can indirectly stimulate cancer by evading immune responses and altering cellular pathways, such as apoptosis and proliferation. This abstract synthesizes evidence from epidemiological, clinical, and experimental research, underscoring the complex interplay between parasitic infections and cancer initiation, and highlighting the need for further investigation into underlying mechanisms and potential therapeutic implications. Findings by Grok Advertisement Advertisement Addendum Reference on cryptosporidia, an often fatal infection. https://pmc.ncbi.nlm.nih.gov/articles/PMC6945992/ Deep sequencing of DNA showed that this was a cancer in an HIV patient caused by a Dwarf Tapeworm, Hymenolepis nana. I am adding H. nana to the roster of cancer causing parasites. This was brought to my attention by Jessica @jessicalanas . Life Cycles of the Above Parasites Below Helminth Opisthorchis viverrini Cryptosporidium Plasmodium mosquito vector Theileriosis Life Cycle, a Zoonosis Protozoan Theileria Tick Borne Protozoan Zoonosis Protozoa in the genus Theileria spp. are tick-borne parasites that have been found in many species of mammals including humans. Helminth Chlonorchis sinensis Hymenolepis nana Dwarf tapeworm SUMMARY. It is logical to assume from the above evidence that various stages of parasites have had a long evolutionary history of invasion of hosts bodies and one must suspect even the spores and larval stages have evolved adaptations to transform their hosts into more pliable victims by using cancer tricks to weaken host immunity. The key to preventing these cancers is to avoid the infective life stages with education and protective equipment and behavioral changes. Research after infection needs to redirect to suitable and proven safe anti-parasite drugs that have demonstrated anti-cancer function. Research investigators should also look at other parasite infections from the oncogenic synergistic perspective such as sarcosystosis from consuming undercooked infected waterfowl and coccidia and tick infections of Babesia microti and others from Dogs. H. Nana infects many millions around the world and is probably widely mistreated by conventional cancer therapies. Antiparasite Drugs https://jyrkkanencanadasaga.wordpress.com/2024/09/30/fenbendazole-and-ivermectin-cancer-treatment-potential-exploration-amazon-ships-both-jorma-jyrkkanen-researcher-2024-09-30/ 2. MY PRESENTATION AT GLOBAL GENETIC DISORDERS CONFERENCE IN STOCKHOLM ON CATCHING CANCER IMPLICATED PARASITES. Jan 2017. Catching Cancer from Infectious Agents, a Silent Global Pandemic of Transmissable Cancers. Jorma Jyrkkanen, Investigator. To this list I would add the bioweapon Sars 2 Covid-19 mRNA vaccine with spike protein, Simian Virus 40 (SV40), mouse mammary tumor virus (MMTV) and the HIV cancer mortality needs to be revisited. SAIMR, CIA and MI5 deliberately infected Africans with AIDS during the Black-White War in South Africa undoubtedly leading to AIDS related cancers. Secret Service is Making Killer Viruses and other Pathogens that may have Escaped P-P with Lateral Gene Exchange Potential. High Crime under Biological Weapons Convention. Ref Dr. Tent. See also for an update. I would like to see AIDS HIV, Sars 2 covid-19, SV40, H5N1 (gain-of-function variants), MMTV. Related Tylenol, Acetaminophen, Aspirin, Suppress Glutathione, Impacting Mitochondria and Total Health Jorma Jyrkkanen, Researcher. 2025-10-04October 4, 2025In "acetaminophen" Epigenetic referencesJanuary 24, 2012In "cancer" Parasites Can Cause Cancer. Jorma Jyrkkanen Researcher 2025-03-16March 16, 2025In "bladder cancer" Tags: carcinogenic infectious agents, Hygiene Education Research, Jorma Jyrkkanen Researcher, mechanisms, Oncoloy, Some Cancers Contagious 3. I DISCOVER IVERMECTIN AND FENBENDAZOLE SUCCESS IN TREATING CANCER PUBLICATIONS INCREASING AND DANDELION ROOT Fenbendazole and Ivermectin Cancer Treatment Potential. Exploration. Cancer Response Supports Hypothesis Cancer is a Highly Evolved Parasite However Metabolism Comparisons Suggest Leishmania. Amazon ships both drugs. IP6 Also Mentioned. Jorma Jyrkkanen, Researcher. 2024-09-30 September 30, 2024, 9:39 pm Filed under: Uncategorized | Tags: antiparasitics, biology, cancer, cancer treatment, experimental, fenbendazole, health, healthcare, immunotherapy, ivermectin, Jorma Jyrkkanen, Jorma Jyrkkanen Analyst, mebenazole, medicine, news, oncology, preliminary, review, veterinary https://jyrkkanencanadasaga.wordpress.com/2024/09/30/fenbendazole-and-ivermectin-cancer-treatment-potential-exploration-amazon-ships-both-jorma-jyrkkanen-researcher-2024-09-30/ EUREKA HUGE TRANSITION IN CANCER RESEARCH INITIATE BY THIS POST EUREKA CASE STUDY PUBLISHED IN ONCOLOGY CANCER CURE W FENBENDAZOLE?!?!? Advertisement Parasites Do Cause Cancers https://jyrkkanenepigeneticsnews.wordpress.com/2025/03/16/parasites-can-cause-cancer-jorma-jyrkkanen-researcher-2025-03-16/ KILLING PARASITES POSSIBLY RIDDING OF CANCERS WITH 1150 HZ TONE AVAILABLE ON CELL PHONES https://dasevolutionvongott.wordpress.com/2026/03/25/1150-hz-anti-parasite-p-frequency-will-probably-kill-p-cancers-and-is-available-on-cell-phones-2026-03-25-jorma-jyrkkanen-researcher/ Canchema Ltd ships through Amazon. I an not a Doctor and am not recommending these products only posting that there has been some success by some with them for some cancers. Go to the Peer Reviewed Journals for the Bill of Goods. MAYBE NOT VERIFIED. Cancers (Basel). 2019 Sep; 11(9): 1284. Published online 2019 Aug 31. doi: 10.3390/cancers11091284 PMCID: PMC6769799 PMID: 31480477 Fenbendazole program suggested by Dr Frank Yap https://www.onedaymd.com/2024/11/fenbendazole-and-cancer-15-minutes-with.html Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature. Andrea Emanuele Guerini,1Luca Triggiani,1Marta Maddalo,2,*Marco Lorenzo Bonù,1Francesco Frassine,1Anna Baiguini,1Alessandro Alghisi,1Davide Tomasini,1,*Paolo Borghetti,2Nadia Pasinetti,3Roberto Bresciani,4Stefano Maria Magrini,1 and Michela Buglione1 Anticancer treatment efficacy is limited by the development of refractory tumor cells characterized by increased expression and activity of mechanisms promoting survival, proliferation, and metastatic spread. The present review summarizes the current literature regarding the use of the anthelmintic mebendazole (MBZ) as a repurposed drug in oncology with a focus on cells resistant to approved therapies, including so called “cancer stem cells”. Mebendazole meets many of the characteristics desirable for a repurposed drug: good and proven toxicity profile, pharmacokinetics allowing to reach therapeutic concentrations at disease site, ease of administration and low price. Several in vitro studies suggest that MBZ inhibits a wide range of factors involved in tumor progression such as tubulin polymerization, angiogenesis, pro-survival pathways, matrix metalloproteinases, and multi-drug resistance protein transporters. Mebendazole not only exhibits direct cytotoxic activity, but also synergizes with ionizing radiations and different chemotherapeutic agents and stimulates antitumoral immune response. In vivo, MBZ treatment as a single agent or in combination with chemotherapy led to the reduction or complete arrest of tumor growth, marked decrease of metastatic spread, and improvement of survival. Further investigations are warranted to confirm the clinical anti-neoplastic activity of MBZ and its safety in combination with other drugs in a clinical setting. Keywords: chemoresistance, radioresistance, mebendazole, repurposing, cancer stem cells, cancer, CSC, anticancer, stemness Source of the Drug Ivermectin also supposed to work on cancer. Do your reading online for both products. Ivermectin Discovery by Satoshi Omura and William C Campbell and its Potentials Kaur B, Blavo C, Parmar MS. Ivermectin: A Multifaceted Drug With a Potential Beyond Anti-parasitic Therapy. Cureus. 2024 Mar 12;16(3):e56025. doi: 10.7759/cureus.56025. PMID: 38606261; PMCID: PMC11008553. Advertisement DISCOVERY IN RUSSIA 1951 ON WORM-CANCER LINK TESTIMONIALS FROM MEDIA AND ONCOLOGISTS 62 YR OLD DRUG IVERMECTIN FIND EARNED A NOBEL PRIZE https://x.com/i/status/1623231931474411521 Advertisement Beneficial Drug for other Ailments including Covid-19 Bio of Ivermectin Discoverers Ramifications of Cancer Response to Antiparasitics: Supports Theory Cancer is a Highly Evolved Parasite. My observation of primitive metabolism in cancer cells and cancer response to Ivermectin and Fenbendazole in my View Cements this as a strong Working Theory; the Hypothesis that Cancer is a new variant of Ancient Parasite that has highly evolved. This Theory gained Credence in 2011 by Peter Duesberg at Berkeley but was Suggested by Julian S Huxley in 1956. Aneuploidy being a characteristic is profoundly developed in Leishmanias so its possible an early form was cancer’s origin but since cancer was present in dinosaurs that transition predated their dominion. If validated insect vectors likely played a part. Metabolism may be the key to discovering the ancient ancestor if cancer is indeed a parasite. Commonalities between Parasites and Cancer Cells Support Common Ancestry 1. survive and proliferate independently of exogenous factors 2. resistant to apoptosis 3. evade host immune system (Ref: turkiyeparazitolder.org) 4. experience aneuploidy 5. respond to antiparastitic drugs Aneuploidy in Leishmanias https://www.embopress.org/doi/full/10.15252/embr.202357413 Aneuploidy a Driver of Cancer https://www.popsci.com/science/article/2011-07/cancers-are-newly-evolved-parasitic-species-biologist-argues/#:~:text=The%20formation%20of%20cancers%20is%20really%20the%20evolution,can%20grow%20however%20it%20wants%2C%20wherever%20it%20wants. Metabolism should verify or refute the evolutionary relations. Viral Vectors Are Able to Phosphorylate the Rb Gene and Advance Cell Cycle. Can Parasites do this or facilitate this? Viral oncogenes such as human papilloma virus E7, simian virus TAg, and adenovirus E1A, can phosphorylate Rb. Parasite infections can facilitate viral infections that can phosphorylate Rb plus dampen the immune system. Drug, pesticide, spike damage to mitochondria can knock out the P53 DNA repair gene thus making the cell cycle immortal ie cause cancer. Even if they don’t directly cause cancer they can facilitate it. Leishmanias input glucose and generate pyruvate like humans Cancer inputs lactate via anaerobic glycolysis Leishmanias metabolism converts glucose to pyruvate like humans and it looks problematic to evolve cancer from it. This weakens the hypothesis of origins. Cancer metabolism differs significantly from both humans and leishmanias weakening but not destroying the LEISHMANIA evolution hypothesis. Ivermectin Updates Advertisement Another Remedy for Cancer Claimed to Help Treat is IP6 derived from Grains and Legumes. ip6 mechanism on cancer A plethora of studies have investigated the anti-cancer properties of IP6 [56,57,58] (Table 1). IP6 and its derivatives, such as IP5, IP4, and IP3, have been shown to possess anti-cancer activities by modulating biological processes implicated in various cancers, including inflammation, apoptosis, angiogenesis, proliferation, cell signaling, and gene expression [31,113,114]. Some studies have highlighted the potential cytostatic and cytotoxic properties of IP6 in malignant cells [59,115,116] (Table 1). Other reported anti-cancer effects of IP6 include boosting immunity and anti-oxidant activities [60] (Table 1). I am not a Doctor prescribing these nature derived medicines. Do your research and assessment and with the advice of your oncologist and only then use them and make sure you understand long term ramifications. Breaking News Doctors Rethinking Cancer as a Parasitic Disease JORMA’S EXPERIMENTAL HOME REMEDY FOR CANCER AND WORMS NOV 2024 If its true cancer is a parasite, my home remedy for worms might cure it or help. A concoction of lemonade, vodka, cloves-eugenol, garlic-allicin, turmeric, cayenne, oregano-thymol and pumpkin seeds-allergenic??. Needs testing and awareness of potential side effects. Beware of negative side effects ex turmeric on the skin. https://www.verywellhealth.com/10-serious-side-effects-of-turmeric-8703958 IVERMECTIN NET OPENED UP What An Expert on Parasites Suggests Re Getting Rid of Them. Parasite Expert Comments on Parasite Cleansing and Associated Cancers Just in Case The Eagle flies free Translated from Spanish “Parasites are ubiquitous, they burrow deeply… All human beings have parasites”… “If you treat them insufficiently ONLY with Ivermectin OR ONLY with Fenbendazole, you will disturb them.” “They will migrate deeply to another organ like the pancreas and you will end up with pancreatic cancer”… Dr. Thomas Lodi, MD. Common Parasites and the Organs They Inhabit: Bovine Tapeworm (Taenia saginata)… can inhabit every organ and then migrate to the brain. Porcine Tapeworm (Taenia solium)… every organ can become infected and eventually go to the brain and spinal cord. Asian Tapeworm (Taenia asiatica)… all organs can be affected. Opisthorchis viverrini and Clonorchis sinensis (Liver Flukes)… reside in the liver and bile ducts. Schistosomiasis (Blood Fluke)… resides in the bladder. Toxoplasmosis… causes eye tumors, meningioma, leukemia, and lymphomas. Cryptosporidium parvum… resides in the digestive tract, mainly colorectal. Trichomonas vaginalis… resides in the cervix and prostate. Ivermectin and fenbendazole are fantastic medications that work miracles, but they have their limitations. There are parasites that even antiparasitic drugs do not eradicate. Tapeworms, liver flukes, blood flukes, adult filarial worms, and intestinal coccidia are not eradicated by ivermectin and fenbendazole. Insufficient treatment will lead to parasitic migration, burrowing deeply into other organs and leading to cancer. Nature has been providing broad-spectrum parasite eradication for thousands of years. 3 natural compounds that kill and bind every parasite for their eradication and elimination from the body. Potent compounds not created in a laboratory, but found in nature. Wormwood, black walnut hulls, and cloves are the triad that targets parasites, inflammation, and terrain dysfunction without ever experiencing side effects or pharmaceutical toxicities… Wormwood: Exactly the same mechanism as ivermectin and fenbendazole for parasites and cancer. Wormwood contains artemisinin, which specifically targets cancer cells while leaving healthy cells intact. Black Walnut Hulls: Exactly the same mechanism as ivermectin and fenbendazole for parasites and cancer. Black walnut is a natural antiparasitic that breaks down biofilms and improves immune function. Cloves: Kills parasitic eggs and dissolves parasitic egg sacs for their elimination from body tissues. It also disrupts hard-to-kill second-stage juvenile parasites not eradicated by pharmaceutical drugs. Equally important is heavy metal chelation, simultaneously with parasite cleansing, as parasites are attracted to and bind to heavy metals. Diet is of utmost concern for treatment and future parasitic infections. Eliminating the parasites’ fuel source, which is sugar. A low-carb, animal-based diet low in glucose and sucrose… deprives parasites of their preferred fuel… Main Natural Dewormers: • Garlic: Consuming 1-2 raw cloves or in milk helps combat worms thanks to its sulfur compounds. • Pumpkin Seeds: Contain cucurbitin, which paralyzes parasites, allowing their expulsion. It is recommended to consume them crushed. • Papaya and its seeds: The seeds contain enzymes that help eliminate intestinal parasites. A mixture of two tablespoons of papaya seeds with water is a popular remedy. • Coconut Oil and Castor Oil: A mixture of both acts as a mild laxative that helps flush out parasites. • Ginger: Contains gingerol, effective against worms and giardia, often taken as an infusion. • Epazote: An infusion of this plant is known for its properties to expel worms, taken on an empty stomach. • Pineapple: Bromelain, an enzyme from pineapple, helps get rid of intestinal parasites…. 4. NEW DISCOVERIES NEW THERAPIES. CANCER TREATMENT ALTERNATE THERAPIES UNDER STUDY PRESENTLY AND REPORTED EFFICACIES. Jorma Jyrkkanen Researcher 5 May 2026 May 4, 2026 Efficacy and cancer types treated with dandelion’s taraxasterol, Tree frog rod bacteria’s Ewingella americana, Ivermectin, Fenbendazole, 1150 Hz Tone, Bee venom for all cancers tested All these agents are primarily supported by preclinical (in vitro cell line and in vivo animal) data, with very limited or no robust human clinical trial evidence for cancer treatment. None are approved as standard cancer therapies. Claims should be approached cautiously; consult oncologists and prioritize evidence-based treatments. Approval by CDC is however subject to the proviso that they are under the wing of a paramilitary organization whose approvals are highly sudpect of ulterior motives. 1. Dandelion’s Taraxasterol (a triterpenoid/sterol from Taraxacum officinale)Efficacy: Preclinical studies show anti-proliferative, pro-apoptotic (e.g., via caspase-3, Bcl-2 modulation), cell cycle arrest (G0/G1 or G1), anti-inflammatory (e.g., TLR4/NF-κB, IL-6/STAT3), and immunomodulatory effects. It can inhibit tumor growth in mouse models and shows synergy with whole dandelion root extracts. Effects are often selective for cancer cells over normal cells in lab settings. Cancer types tested: • Hepatocellular carcinoma (HCC/liver): Strongest evidence; inhibits growth in HepG2/Huh7 cells and H22 mouse models. nature.com • Colorectal: Inhibits LPS-induced viability via TLR4/NF-κB; part of dandelion root extract activity. pubmed.ncbi.nlm.nih.gov • Others: Melanoma, papillary thyroid, prostate (androgen-independent), breast, cervical, gastric, lung (preclinical). mdpi.com Human data: No established clinical trials for taraxasterol or dandelion extracts as cancer monotherapy. Dandelion has traditional use and some extract studies, but human evidence is insufficient. 2. Ewingella americana (Gram-negative rod bacterium from Japanese tree frog gut)Efficacy: Recent 2025 preclinical work shows remarkable dual action—direct cytotoxicity (via cytolysins in hypoxic tumor cores, proliferating ~3000-fold in tumors) plus strong immune activation (T cells, B cells, neutrophils). A single IV dose led to 100% complete tumor elimination in mouse models, outperforming anti-PD-L1 immunotherapy and doxorubicin, with apparent immune memory (no tumors on re-challenge) and low toxicity at effective doses. Cancer types tested: Primarily colorectal cancer in mouse models (complete responses). Potential for solid tumors exploiting hypoxic environments, but data are limited to this. Human data: None; very early preclinical discovery (2025). Not tested in humans.3. Ivermectin (antiparasitic drug)Efficacy: Preclinical data indicate effects on proliferation, apoptosis, metastasis inhibition, multidrug resistance reversal, and potential synergy with immunotherapy/chemotherapy (e.g., via PAK1 inhibition or other pathways). Doses in lab studies often exceed safe human antiparasitic levels. Cancer types tested (preclinical): Broad range including breast (TNBC), ovarian, colorectal, lung, glioma, etc. Human data: Limited. Ongoing/early Phase I/II trials (e.g., with balstilimab or pembrolizumab in metastatic triple-negative breast cancer) show safety but mixed/minimal added benefit so far in small cohorts (e.g., one PR, mostly PD/SD in preliminary data). No strong evidence of standalone efficacy. Self-use is reported but not recommended. 4. Fenbendazole (veterinary anthelmintic, benzimidazole)Efficacy: Preclinical: Microtubule disruption (like some chemotherapies), apoptosis/pyroptosis induction, glycolysis inhibition (e.g., HK2), anti-proliferative effects. Works in cell lines and some mouse xenografts (e.g., lung, breast). Synergy with other agents reported. Bioavailability challenges for oral use in humans/animals. Cancer types tested (preclinical): Lung (A549), breast, colorectal, cervical (HeLa), ovarian, prostate, melanoma, leukemia, etc. Case reports (self-administration) claim responses in advanced breast, prostate, melanoma. Human data: No approved or large randomized trials. Anecdotal case series and self-reports exist, but confounded. Safety in humans is not well-established for cancer dosing; liver monitoring advised. Ongoing interest but unproven. 5. 1150 Hz Tone (Rife-like frequency therapy)Efficacy: No credible scientific evidence. Claims stem from discredited Rife machine ideas (specific frequencies “shatter” pathogens/cancer cells). Sound at this frequency has no demonstrated anticancer effect. Cancer types: None validated. Modern focused ultrasound/histotripsy (high-intensity, not audible tones) is a separate, approved technology for liver tumors (mechanical disruption), unrelated to 1150 Hz. Human data: None supporting efficacy for cancer. Fact-checks debunk parasite/cancer-killing claims for such frequencies. 6. Bee Venom (primarily melittin peptide)Efficacy: Preclinical: Melittin disrupts cancer cell membranes (pore formation), induces apoptosis, inhibits growth factor signaling (e.g., EGFR/HER2, PI3K/Akt), reduces metastasis. Selective for some cancer cells vs. normal at certain doses. Nanoparticle formulations improve targeting/safety. Synergy with chemo/radiation reported. Cancer types tested (preclinical): Strongest for breast (TNBC, HER2-enriched—near-complete cell death in lab), also prostate, ovarian, cervical, lung, melanoma, etc. Reduces tumor growth/metastases in mouse models. Human data: Very limited early-phase (e.g., intratumoral injections in solid tumors showed some tolerability/shrinkage). No large trials; delivery/toxicity challenges remain (e.g., hemolysis risk). Not standard therapy. Summary Table of Evidence Level: • Strongest preclinical: Ewingella (dramatic mouse CR), Bee venom/melittin (breast), Taraxasterol (HCC/colorectal), Fenbendazole/Ivermectin (broad). • Human evidence: Minimal (early trials for ivermectin + IO in TNBC; anecdotes for fenbendazole; safety pilots for melittin). • None recommended as substitutes for proven therapies. These may have future adjunct potential if trials succeed, but risks include toxicity, interactions, or delayed standard care. Always rely on oncology teams for decisions. • Preclinical, anti-proliferative, pro-apoptotic, cell cycle arrest, anti-inflammatory, immunomodulatory effects, inhibit tumor growth, mouse, synergy, selective for cancer, cells over normal cells in lab settings. • Melanoma, papillary thyroid, prostate (androgen-independent), breast, cervical, gastric, lung (preclinical) • single IV dose led to 100% complete tumor elimination in mouse models • Fenbendazole Cancer types tested (preclinical): Lung (A549), breast, colorectal, cervical (HeLa), ovarian, prostate, melanoma, leukemia, etc. Case reports (self-administration) claim responses in advanced breast, prostate, melanoma. • Sound tone no demonstrated cancer effect. Experiments needed. Parasite kill frequencies validation IN PROGRESS • • PS FOOTNOTE MAJOR CONCLUSION. VIRUSES AND BACTERIA AND PROTOZOA THAT INFECT ANIMALS AND CAN CAUSE CANCER CAN BE RECLASSIFIED AS PARASITES AND TREATED ACCORDINGLY, CHEMICAL FORMULAE BELOW, BEST HOPE IS THE COLORED ONE a rod bacteria in tree frogs EWINGELLA americana 1 dose 100% cure no recurrence.