POTENTIAL ANTIBIOTIC INDUCED MITOCHONDRIAL HARM REDUCTION WITH DRUGS AND VITAMINS AND NUTRIENTS
PHC1 alpha and AMPK and I have to become more familiar if I am to seek therapies for antibiotic (AB) induced mitochondrial dysfunction. Maybe a pharmacological opportunity lies within. Rosiglitazone and metformin diabetic drugs for type 2 increased mitogenesis and may be a potential therapy for antibiotically damaged mitochondria and combined with vitamin C (absorbs ROS) D (reduces cancer risk of damaged mitochondria)and E (absorbs Lipid Peroxide)and N-acetyl-l-cysteine antioxidant (Calghatgi 2013) provides a tool kit to experiment with in the case of AB induced glutathione deficiency. Anti-inflammatories like myrrh, frankinsence, curcumin and commercially available glutathione oral spray may also be helpful to reduce carcinogenic and cardiopathology potential (Ref Jorma Jyrkkanen. 2021-05-15). I do not think antibiotic
s should be given to covid patients under any circumstances. It creates a double hit on the mitochondria. Last image is mitochondrial rupture by antibiotics.
Periodic fasting helps boost mitochondrial replacement (Dr. Jason Fung. The CANCER CODE. PG 225 and a 3 day fast helps reset the immune system with potential benefits for mitochondrial deficits and cancer prevention (Fasting triggers stem cell regeneration of damaged, old immune system by shitting down the PKA gene (Suzanne Wu June 5, 2014).
MITOCHONDRIAL INTERVENTIONS
Presently, a large number of drugs are being repurposed against COVID-19 disease. These include, e.g., remdesivir, lopinavir/ritonavir, and anti-inflammatory agents such as chloroquine and tocilizumab (21, 38). It is likely that drugs that modulate mitochondrial function and inhibit inflammation may help treat patients with COVID-19.
Figure 9 provides the schematic describing the conceptual framework related to SARS-CoV-2 hijacking of mitochondria resulting in COVID-19 disease. A schematic shows how the SARS-CoV-2 enters into the host cell utilizing ACE2, a polymorphic protein that regulates mitochondrial function. Upon entry into the cells, viral RNA and RNA transcript translocate to mitochondria to hijack and manipulate host mitochondria to suppress host immunity. We do not yet know how CoV-2 RNA localized to mitochondria to impact immunity. It is likely that it involves multiple mitochondrial mechanisms at different levels. Conceivably, postinfection noncoding RNA may regulate USP30, a host protein that controls mitochondrial dynamics (fission and fusion). SARS-2-CoV-2 also can manipulate the release of mtDNA, leading to inflammation. Thus, the hijacking of mitochondria may be an essential mechanism in the induction of COVID-19 disease. These observations suggest that drugs that selectively restoreDecoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis (Ref American Journal of Physiology. Cell Physiology.
Keshav K. Singh Gyaneshwer Chaubey, Jake Y. Chen and Prashanth Suravajhala
20 Jul 2020https://doi.org/10.1152/ajpcell.00224.2020 mitochondrial function and promote mitochondrial biogenesis may serve as anti-inflammatory agents to prevent or treat COVID-19.)
Follow up tests looking for cytokine storms-Blood ferretin, clotting-use D-dimer and mitochondrial function-use lactose/pyruvate >20/1.
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In a Major Twist, Human Cells Found Writing RNA Into DNA
WRITTEN BY: Carmen Leitch
For many years, scientists have known about one of the most fundamental processes in biology, where cells use a DNA sequence to transcribe an RNA molecule, and use that to generate a protein. But we're also learning that things can get far more complex than that. Not all RNA molecules are used to generate protein, for example. It's long been thought that enzymes called DNA polymerases only function to copy the genome or make repairs to DNA. But now, scientists have found evidence of reverse transcription, in which RNA molecules get written as DNA, in mammalian cells.
Reduce risk of antibiotic damage from mitochondria these foods have potential to supplement reduced glutathione: Broccoli, spinach, carrots and potatoes are all high in antioxidants, and so are artichokes, cabbage, asparagus, avocados, beetroot, radish, lettuce, sweet potatoes, squash, pumpkin, collard greens and kale. Using lots of spices in cooking is good.
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