Egg Yolk anti-spike-S1-IgYs Antibodies Neutralize Spike. RePost. 2023-02-02 Jorma Jyrkkanen

Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2 Shuangshi Wei 1 , Shengbao Duan 2 , Xiaomei Liu 1 , Hongmei Wang 1 , Shaohua Ding 1 , Yezhou Chen 1 , Jinsong Xie 1 , Jingjing Tian 1 , Nong Yu 3 , Pingju Ge 4 , Xinglin Zhang 4 , Xiaohong Chen 4 , Yong Li 5 , Qinglin Meng 6 Affiliations PMID: 33191178 PMCID: PMC7608017 DOI: 10.1016/j.intimp.2020.107172 Abstract The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19. Keywords: Chicken Egg Yolk Antibodies; IgY; Neutralizing agent; SARS-CoV-2; Spike protein variants. Free PMC article In summary, the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various S mutants, and even SARS-CoV in vitro. However, the safety and efficacy of the IgYs still needs further interrogation in animal models. At present, the SARS-CoV-2 virus is still spreading around the world, and there is much to be done to prevent and control the pandemic. The use of IgYs in aerosol or spray formulations on the respiratory tract, the oral cavity, and even the digestive tract may be a worthwhile strategy. It might prevent the invasion of the SARS-CoV-2 virus through the natural infection route. Long-term control of the SARS-CoV-2, however, will require a combination of active and passive immunization tools, drug therapy, and other preventive measures.